Treating cancer when pRb and p53 cannot be reactivated
نویسنده
چکیده
Activation of oncoproteins and inactivation of tumor suppressors induces tumorigenesis. When these events happen upstream of pRb and p53, cancer therapies may initially succeed and then fail when pRb and p53 are activated and then re-inactivated. Therapies might succeed if they remain effective when pRb and p53 are genetically inactivated.
منابع مشابه
The prognostic value of the AgNOR parameter in human breast cancer depends on the pRb and p53 status.
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